中文摘要：

目的探讨精神病风险综合征（clinical high risk of psychosis,CHR）者听觉事件相关电位P300波幅、潜伏期以及认知功能的特征。方法采用Oddball范式,对36例CHR者（研究组）和35名正常对照（对照组）进行事件相关电位P300测定,利用MATRICS成套认知测试评估两组被试认知功能,中文版精神病风险综合征定式访谈中精神疾病高危症状量表（scale of psychosis-risk symptoms,SOPS）评估CHR者临床症状。结果研究组信息处理速度、注意/警觉性、工作记忆、词语学习、视觉学习、推理和问题解决以及社会认知等7个领域认知功能得分均差于对照组（P〈0.01）。研究组Fz、Cz、Pz导联P300波幅比对照组降低（P〈0.05）,Pz导联P300潜伏期延长（P〈0.05）。研究组Cz点P300潜伏期与SOPS阳性症状得分呈正相关（r=0.544,P=0.001）,P300波幅与信息处理速度（言语流畅性）得分呈正相关（r=0.339,P=0.043）。结论 CHR者认知功能、事件相关电位P300存在异常。P300与CHR精神病症状、认知缺陷存在一定的相关性,提示其在精神病风险监控中的作用值得重视。

英文摘要：

ObjectiveTo investigate the characteristics of auditory P300 amplitude and latency and cognition inpatients with clinical high-risk of psychosis（CHR）.MethodThirty six CHR（study group） and thirty five healthy con-trols（control group） were included. Oddball paradigm and MATRICS Consensus Cognitive Battery（MCCB） were used torecord auditory P300 and to evaluate the cognition, respectively. The structured interview for psychosis-risk syndromes（SIPS） was used to evaluate the clinic symptoms of patients.ResultThe cognition of CHR was significantly lower thanhealthy controls in information processing, attention/vigilance, working memory, verbal learning, visual learning, reason-ing and problem solving and social cognition（P0.01）. The study group showed decreased amplitude in Fz, Cz and Pzand delayed latency in Pz（P0.05）. P300 latency of CHR in Fz positively correlated with positive score of SOPS（r=0.544, P=0.001）, while P300 amplitude positively correlated with verbal fluency（r=0.339,P=0.043）.ConclusionCogni-tion and P300 is abnormal in CHR. The correlation between P300 and clinical symptoms, cognitive dysfunction remindsthat we should put more attention on the role of P300 in CHR subjects.