中文摘要：

在细胞外的 striatal 上调查 echinacoside 的效果的目的新肾上素( NE )铺平，多巴胺( DA )， homovanillic 酸( HVA )， 3 ， 4-dihydroxyphenylethanoid 酸( DOPAC )， 5-hydroxyindoleacetic 酸( HIAA )，并且在中间的服的动脉吸藏的 5-hydroxytryptamine ( 5-HT )( MCAO 老鼠。中间的服的动脉在男 Sprague-Dawley 老鼠被堵塞的方法。三天以后， microdialysis 探针被放进 MCAO 老鼠大脑的正确 striatum，大脑以 1.5 的率与 Ringer 的答案被酒 ??  ???? 挠灥慨潬潰楤浵吗？？

英文摘要：

Objective To investigate the effects of echinacoside on the extracellular striatal levels of norepinephrine（NE）,dopamine（DA）,homovanillic acid（HVA）,3,4-dihydroxyphenylethanoid acid（DOPAC）,5-hydroxyindoleacetic acid（HIAA）,and 5-hydroxytryptamine（5-HT） in middle cerebral artery occlusion（MCAO rats.Methods The middle cerebral artery was occluded in male Sprague-Dawley rats.Three days later microdialysis probes were placed into the right striatum of MCAO rat brains and the brains were perfused with Ringer＇s solution at a rate of 1.5 μL/min.Cerebral microdialysates were collected every 30 minutes from awake and freely moving rats before assaying for NE,DA,HVA,DOPAC,HIAA,and 5-HT levels by reverse phase HPLC with electrochemistry.Results Three days after MCAO,the extracellular striatal levels of NE,DA,DOPAC,HIAA,HVA,and 5-HT of the MCAO rats increased significantly（at least P0.05 vs.control）.However,simultaneous treatment with echinacoside（30.0 or 15.0 mg/kg） attenuated these increases（at least P0.05 vs.non-treated model rats）.Conclusion These results imply that echinacoside may protect striatal dopa minergic neurons from the injury induced by MCAO and may help prevent and treat cerebral ischemic diseases.