中文摘要：

4-（苯并[d][1,3]二氧戊环-5-基）-2-（3,4-二甲氧基苯基）-4-氧代丁腈经水解、还原反应得4-（苯并[d][1,3]-二氧戊环-5-基）-2-（3,4-二甲氧基苯基）丁酸;再经傅克反应、刘卡特反应、环合得2,3-亚甲二氧基-8,9-二甲氧基-4b,10b,11,12-四氢苯并[5,6-c]菲啶;最终通过芳构化、硫酸二甲酯甲基化并经氯化钠盐交换得氯化两面针碱。优化后工艺总收率为2.5%,操作简便,反应条件温和,原料和试剂经济易得。

英文摘要：

Nitidine chloride was synthesized from 4-（benzo [d] [1,3] dioxol-5-yl）-2-（3,4-dimethoxyphenyl）-4- oxobutanenitrile via hydrolysis and reduction to give 4-（benzo[ 1,3] dioxol-5-y1）-2-（3,4-dimethoxyphenyl）butanoic acid, subsequent Friedel-Crafts cyclization, Leuckart reaction, and cyclization to obtain 2,3-methylenedioxy-8,9-dimethoxy- 4b,10b, 11,12-tetrahydrobenzo [5,6-c] phenanthridine, which was subjected to aromatization with Pd/C, followed by methylation with dimethyl sulfate and salt exchange with sodium chloride. The total yield was 2.5 % in the optimized process, all the reaction conditions were mild, and the reagents were cheap and commercial available.