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中文摘要：
为了从氰基丙烯酸酯类化合物中寻找新的活性化合物，通过活性亚结构拼接方法，设计并合成了一系列未见文献报道的新型含1，3，4-噁二唑环的氰基丙烯酸酯类化合物.采用核磁共振氢谱、碳谱和元素分析确认了目标化合物的结构.初步的生物活性测试结果显示，在1500 g/ha剂量下，化合物8b对繁缕的茎叶处理抑制率为80%.化合物8j对小藜的茎叶处理抑制率为70%.另外，化合物8e，8k，8m和8n对人肝癌细胞株表现出较好的抗肿瘤作用，其IC50值分别为8.2，5.9，8.0和12.6 μmol/L.
英文摘要：
In order to find new cyanoacrylate lead compounds, a series of novel cyanoacrylates carrying 1,3,4-oxadiazole moiety were prepared by the method of active substructure combination. The structures of the title compounds were characterized by ^1H NMR, ^13C NMR and elemental analysis. Preliminary bioassay data displayed that in postemergence treatment compound 8b had 80% herbicidal activity against Stellaria media at 1500 g/ha and compound 8j showed 70% herbicidal activity against Chenopodium serotinum L. at 1500 g/ha. Additionally, compounds 8e, 8k, 8m and 8n exhibited good anti-tumor activity against HepG2 cells with the IC50values of 8.2, 5.9, 8.0 and 12.6 μmol/L, respectively.
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