中文摘要：

目的探讨双酚A（BPA）、辛基酚（OP）、4-壬基酚（4-NP）与性早熟女童发病的关系。方法收集2005年3～10月在复旦大学附属儿科医院性早熟专科门诊就诊的初诊性早熟女童110例,正常女童100例,运用高效液相色谱法测定患儿和正常女童血清BPA、OP、4-NP的含量,同时测定子宫、卵巢体积及血清中雌二醇含量,将血清中BPA、OP、4-NP含量与靶器官的临床指标作相关性分析。结果40.9%和33.6%的性早熟女童血清中分别检测出BPA和OP,而正常女童仅2%和5%分别检测出BPA和OP,24.5%性早熟女童血清检测出4-NP,3%正常女童血清检测出4-NP;性早熟女童血清中BPA、OP、4-NP构成比均高于正常女童（P〈0.01）;性早熟女童血清中BPA含量与子宫体积呈正相关（r=0.557,P〈0.05）,与卵巢体积呈正相关（r=0.469,P〈0.01）,血清中OP含量与子宫体积呈正相关（r=0.576,P〈0.05）,与卵巢体积呈正相关（r=0.676,P〈0.01）。结论性早熟女童受BPA、OP、4-NP污染的程度均比正常女童严重得多,而且BPA、OP对子宫、卵巢体积有影响,可能与性早熟女童的发病有一定关系。

英文摘要：

Objective To investigate the role of bisphenol A（BPA）,octylphenol（OP）,4-nonylphenol（4-NP） causing precocious girls.Methods The blood samples were collected from 110 cases of precocious girls and 100 cases of normal girls.The concentrations of BPA,OP,4-NP in serum samples were measured by using high performance liquid chromatography（HPLC）,the volume of the uteruse and ovary,the content of estradiol（E2） were determined at the same time.The contents of BPA,OP,4-NP in blood serum of precocious girls and the indices of the target organs were analyed by using correlation.Results BPA and OP were detected in blood serum for 40.9% and 33.6% of precocious girls respectively,BPA and OP were detected for only 2% and 5% in normal girls respectively,4-NP was detected for 24.54% of precocious girls and 3% of normal girls.The ratio of BPA,OP,4-NP in blood serum of precocious girls was higher than normal girls respectively （P〈0.01）,BPA in blood serum of precocious girls patients was positive correlation with the volume of the uterus（r=0.557,P〈0.05 ）,and positive correlation with volume of the ovary（ r=0.469,P〈0.01）.OP in blood serum of precocious girls patients was positive correlation with the volume of uterus（r=0.576,P〈0.05）,positive correlation with volume of ovary（r=0.676,P〈0.01 ）.Conclusion Precocious girls patients were contaminated more severely than normal girls,and BPA、OP could influence the volume of the uterus and ovary,so it had some relationship with cause of precocious girls.