中文摘要：

本文根据己报道的非ATP竞争型cHK1抑制剂，设计并合成了分别具有吡咯并嘧啶和嘌呤结构的两类脲类化合物作为新型非ATp竞争型cHK1抑制剂，并进行了初步的生物活性测试。结果显示，大部分化合物尤其是嘌呤系列化合物17f不仅对CHK1的抑制活性高于先导化合物，而且展现出一定的抗肿瘤增强作用。

英文摘要：

A series of urea-based compounds containing purine moieties were designed and synthesized as novel non-ATP competitive CHK1 inhibitors. The biological evaluation showed that several target compounds exhibited more potent inhibitory effects against CHK1 than the lead compound. In addition, one particular compound displayed synergistic effects with gemcitabine against HT29 cells.