中文摘要：

为了合成具有抗菌活性的红霉素衍生物，本文以红霉素A为原料，合成了6-位烯丙基取代中间体12，21-双键-2’-O，4＂-O-二苯甲酰基-（9S）-9-O，11—O-异丙基-6—O-烯丙基红霉素A12，得到（9S）-9-羟基-12-亚甲基衍生物6和6，7-去氢-（9S）-9-羟基-12-亚甲基衍生物11。经^13C NMR，FAB—MS确证产物结构。所得化合物进行了体外抗菌活性测定。6和11均显示出较弱的抑菌活性。

英文摘要：

The derivatives of （9S）-9-hydroxyl-12-methylene erythromycin A were synthesized by using erythromycin A as a starting material. An intermediate （9S） -9,11-O-isopropylidene-6-O-allyl-2＇,4＂- O-bis（benzoyl）-12,21-anhydro erythromycin A 12 was obtained. The antibacterial activity in vitro of two compounds, 6 and 11, was tested. The preliminary biological test showed that two compounds exhibited less potent antibacterial activity in vitro.