目的 探讨慢性肾脏病(CKD)5期行规律腹膜透析患者腹主动脉钙化(AAC)的患病率及其相关危险因素.方法 入选上海交通大学医学院附属仁济医院腹膜透析中心稳定的接受规律腹膜透析的CKD5期患者,采集患者的人口统计学资料,测定血压,检测生化指标,评估患者的残余肾功能和透析充分性,使用腹部侧位X线平片检测患者的AAC情况并进行评分.采用Logistic回归分析分析腹主动脉钙化的危险因素.结果 共有206例腹膜透析患者入选本研究,其中男性108例(52.4%),平均年龄(55.6± 15.0)岁,中位透析龄20(8,44)个月,35例(17.0%)合并糖尿病.在这206例患者中,118例(57.3%)可见腹主动脉钙化,49例(23.8%)可见严重腹主动脉钙化(钙化累及3个节段及以上).与腹主动脉无钙化的患者相比,腹主动脉钙化患者的年龄[(62.3±11.9)岁比(46.7±13.9)岁,P<0.01]、透析龄[28(11,57)个月比16(7,29)个月,P<0.01]较大;原发病为糖尿病肾病的比例(18.6%比6.8%,P<0.05)和合并糖尿病的比例(23.7%比8.0%,P<0.01)较高;脉压[52.0(44.0,66.3) mmHg比48.0(40.0,58.0) mmHg,P<0.05]较高,舒张压[(81.4±11.7) mmHg比(88.6±14.6) mmHg,P<0.01]、平均动脉压[(99.6±13.3) mmHg比(104.8±15.1) mmHg,P<0.05]较低;高敏C反应蛋白[2.8(0.7,5.6)mg/L比1.1(0.3,4.4) mg/L,P<0.05]较高;血清白蛋白[(36.9±4.5)g/L比(38.7±4.5) g/L,P<0.01]、前白蛋白[(373.2±89.1) g/L比(404.9±74.7) g/L,P<0.01]、高密度脂蛋白[1.1(0.9,1.4)mmol/L比1.3(0.9,1.5) mmol/L,P<0.05]较低;总Ccr[(59.1±18.9) L·周^-1·(1.73 m2)^-1比(67.8±29.8) L·周^-1·(1.73 m2)^-1,P<0.05]较低.Logistic回归显示年龄(OR=1.104,95%CI 1.071~1.138,P<0.01)、钙磷乘积(OR=1.467,95%CI 1.037~ 2.074,P<0.05)是腹膜透析患者AAC的独立危险因素,残余肾功能(OR=0.858,95%CI 0.740 ~ 0.995,P?
Objectives To evaluate the incidence and risk factors of abdominal aortic calcification (AAC) in chronic kidney disease (CKD) stage 5 patients undergoing peritoneal dialysis (PD).Methods Eligible CKD stage 5 patients undergoing PD in Renji Hospital,Shanghai Jiao Tong University School of Medicine were enrolled in present study.Demographic features,blood pressure,laboratory parameters,residual renal function (RRF),dialysis adequacy and medication were determined.Lateral abdominal X-ray plain film was used to assess AAC,and abdominal aortic calcification score (AACS) was calculated.Risk factors for AAC were analyzed by Logistic regression.Results A total of 206 PD patients aged (55.6± 15.0) years with median PD duration 20 (8,44) months were enrolled in present study.Among them,108 (52.4%) patients were males and 35(17,0%) complicated with diabetes mellitus.AAC was presented in 118 (57.3%) patients,and 49 (23.8%) patients had severe calcification (calcification involving more than 3 lumber segments).Compared to those without AAC,patients with AAC were elder [(62.3±11.9) years old vs (46.7±13.9) years old,P 〈 0.01],had longer PD duration [28(11,57) months vs 16(7,29)months,P 〈 0.01],higher diabetic nephropathy (18.6% vs 6.8%,P 〈 0.05)and diabetic incidence (23.7% vs 8.0%,P 〈 0.01)proportion,higher pulse pressure [52.0(44.0,66.3) mmHg vs 48.0(40.0,58.0) mmHg,P 〈 0.05],lower diastolic blood pressure[(81.4±11.7) mmHg vs (88.6±14.6) mmHg,P 〈 0.01] and mean arterial pressure [(99.6± 13.3) mmHg vs (104.8±15.1) mmHg,P 〈 0.05],higher high-sensitivity C-reactive protein [2.8(0.7,5.6) mg/L vs 1.1(0.3,4.4) mg/L,P 〈 0.05],lower serum albumin [(36.9±4.5) g/L vs (38.7±4.5) g/L,P 〈 0.01],pre-albumin [(373.2±89.1) g/L vs (404.9±74.7) g/L,P 〈 0.01],high density lipoprotein [1.1(0.9,1.4) mmol/L vs 1.3(0.9,1.5) mmol/L,P 〈 0.05],and total creatinine clearance rate [(59.1 ± 1