中文摘要：

富含脯氨酸的酪氨酸激酶2（Pyk2）为粘着斑激酶家族重要成员之一，高表达于中枢神经系统及造血系统。 Pyk2可使多种含SH2结构域的底物蛋白发生磷酸化，从而参与包括离子通道激活、应激反应、细胞黏附、骨架重组以及囊泡运输等多种信号转导通路的调节，使细胞迁移、存活、增殖等能力发生相应的改变，提示 Pyk2可能成为疾病治疗的靶点。目前针对Pyk2的药物研发主要集中在治疗癌症、骨质疏松症、免疫系统疾病等方面。该文将主要对Pyk2的结构域、调控机制及潜在的治疗作用进行综述，为其药物研发提供理论依据。

英文摘要：

Pyk2（Proline-rich tyrosine kinase 2） is an important member of focal adhesion kinase family. Pyk2 is highly ex-pressed in the central nervous system and the hematopoietic sys-tem . Pyk 2 can trigger a variety of SH 2 domain-containing proteins to phosphorylate their substrates, thus it can participate in the regulations including ion channel activation, stress response, cell adhesion, cytoskeleton reorganization, vesicle transport and so on. Through the regulations above, the ability of cell migra-tion, survival, proliferation changes accordingly, suggesting that Pyk2 in many important regulatory processes may become a tar-get for clinical effects. Current drug development for Pyk2 mainly focuses on cancer, osteoporosis and immune response. This review illustrates the domain structure, regulatory mechanisms, potential drug targets, and the drug development of Pyk2 based on the above three fields, which will provide a theoretical basis for clinical treatment.