中文摘要：

目的：研究尼古丁对大鼠局灶性脑缺血再灌注损伤是否具有神经保护作用。方法：在大鼠大脑中动脉堵塞（MCAO）前30min给予腹腔注射尼古丁酒石酸盐溶液,观察局灶性脑缺血2h再灌注24h后,大鼠神经行为学评分及脑梗死容积的变化。结果：再灌注24h后,与单纯缺血再灌注组相比,给予尼古丁酒石酸盐溶液注射可以改善动物的神经行为学评分、减少脑梗死容积百分比（P〈0.05）。结论：尼古丁对大鼠局灶性脑缺血再灌注损伤具有神经保护作用。

英文摘要：

Objective：To explore whether nicotine has a neuroprotective effect on the focal cerebral ischemia/reperfusion（I/R）injury in rats.Methods：Thirty min after the injection of nicotine ditartrate,focal cerebral ischemia was induced by middle cerebral artery occlusion（MCAO）for 120 min in male Sprague-Dawley rats.The neurobehavioral scores,infarct volumes were evaluated at 24 h of reperfusion.Results：After 24 h of reperfusion,nicotine ditartrate injection improved neurological outcome and reduced infarct size（P〈0.05）.Conclusion：These results suggest that nicotine can have neuroprotection against I/R injury.