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中文摘要：
在人类，口腔恶性肿瘤十分常见且发病率高，对人类的健康和生命构成了极大的威胁。自然杀伤细胞2族成员D（NKG2D）与其配体主要组织相容性复合体1类相关分子结合可激活自然杀伤细胞，在肿瘤发生的早期启动机体的固有免疫监视和清除作用。NKG2D的配体主要有主要组织相容性复合体1类相关分子A和B以及UL16结合蛋白，深入研究NKG2D及其配体在口腔肿瘤免疫中的调节作用，有助于发掘新的有效对抗口腔肿瘤的治疗方式。本文就NKG2D及其配体在口腔肿瘤免疫中的调节作用等研究进展作一综述。
英文摘要：
Oral malignancy, a very common disease with high incidence in humans, poses great threats to human health and life. The activating receptor natural killer group 2 member D（NKG2D） and its ligands play important roles in the immune response to oral tumors by initiating innate immune surveillance and immune clearance at the early stage of tumorigenesis. Two types of ligands have been observed, namely, major histocompatibility complex 1 class-related molecule A and B and UL 16-binding protein. Extensive studies on the function of NKG2D and its ligands in oral tumor immunity are helpful in discovering new approaches against oral cancer. This review presents research progress on the immunoregulatory effects of NKG2D receptor and its ligands on oral tumors.
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