中文摘要：

目的探讨原发性高血压（高血压）患者高尿酸血症（hyperuricemia，HUA）与肾脏功能损害及血浆致动脉硬化指数（atherogenicindexofplasma，AIP）的相关性。方法纳入231例高血压患者进行血尿酸浓度检测，将患者分为HUA组（男性尿酸浓度≥420μmol／L或女性≥360txmol／L）和尿酸正常组（男性尿酸浓度〈420μmol／L或女性〈360μmol／L）。测定患者的空腹血糖、血脂、血尿素氮（bloodureanitrogen，BUN）、血肌酐（seYumcreatinine，Scr）、尿微量白蛋白（microalbuminuria，MAU）及胱抑素C（cystatinC，Cys—C）等浓度。计算AIP和肾小球滤过率（estimated异IomemIarfiltrationrate，eGFR）。应用SPSSl3．0统计软件进行分析。结果HUA高血压患者的BUN、Scr、MAU及Cys—C浓度显著高于尿酸正常组．而eGFR显著低于尿酸正常组，差异有统计学意义（P〈0．05）。HUA组患者的AIP高于尿酸正常组，但差异无统计学意义（P=0．223）。高血压患者血尿酸浓度随着AlP四分位数的增加而逐渐升高（F=0．976，P=O．405），但差异均无统计学意义。高血压患者血尿酸浓度与AIP呈显著正相关（r=0．144，P=0．032）。结论HUA高血压患者会造成不同程度的肾损害，动态观察高血压患者的AIP有助于早期识别其罹患动脉粥样硬化的风险。

英文摘要：

Objectives To investigate the relationships of hyperuricemia （HUA）, renal damage and atherogenic index of plasma （AIP） in patients with primary hypertension. Methods A total of 231 hypertensive patients were divided into two groups according to the concentration of plasma uric acid ： HUA group （ male ≥ 420 μmol/L or female ≥ 360μmol/L） and control group （male〈420 μmol/L or female〈360 μmol/L）. Fasting plasma glucose, blood lipid, blood ureanitrogen （BUN）, serum ereatinine （Ser）, microalbuminuria （MAU） and eystatinC （Cys-C） were dynamically monitored by automatic biochemaical analyzer. AlP was calculated by the formula （AIP=lgTG/HDL-C）. Estimated glomerular filtration rate （eGFR） was calculated by the Cockroff-Gault formula. All the data were analyzed by SPSS 13.0 software. Results Concentrations of BUN, Scr, MAU and Cys-C were significantly higher in HUA group than in control group, and eGFR was significantly lower in HUA group than in control group （P〈0.05）. AlP in HUA group was higher than that in control group, however, no significant difference was observed （P=0.223）. Concentration of blood uric acid elevated with the increase of the quartile of AIP （F=0.976, P=0.405 ）. Concentration of plasma uric acid was correlated with AIP （r=0.144, P=0.032）. Conclusions Hypertensive patients with HUA were inclined to suffer from renal damage. Dynamic observation on AlP might be helpful in early identifying the risk of developing atherosclerosis in hypertensive patients with HUA.