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中文摘要：
目的：研究天竺桂挥发油（CJO）的镇痛及抗癫痫作用。方法：天竺桂挥发油的镇痛药理实验采用扭体法、小鼠甩尾法等，抗癫痫作用采用最大电休克（MES）急性惊厥模型试验与戊四唑（PTZ）惊厥模型。结果：小剂量的天竺桂挥发油可显著减少醋酸致小鼠扭体次数及甩尾次数，镇痛效果明显；CJ050mg·kg^-1剂量组可明显降低MES惊厥率、显著延长PTZ潜伏期，但随剂量增加，抗癫痫作用减弱。结论：小剂量天竺桂挥发油具有明显的镇痛作用与良好的抗癫痫作用。
英文摘要：
OBJECTIVE To investigate the analgesic effect and antiepileptic effect of Cinnamomurn japonicum volatile oil （CJO） in animal models. METHODS Cinnarnomum japonicum volatile oil was extracted by steam distillation, the analgesic effect of CJO was observed by body-writhing and tail-flicking method in mice, the antiepileptic effect was studied by MES acute convulsions model test and PTZ convulsions models. RESULTS Low-dose of CJO had obvious analgesic effect, it could significantly reduce the times of body-writhing and tail-flicking in mice, treatment with 50 mg.kg-ldose of CJO, it could visibly decrease the rate of MES seizures and significantly prolonged incubation period of PTZ seizures, but the antiepileptie effect of CJO was weakened with the increase of the dose. CONCLUSION Low-dose of CJO has evident analgesic effect and good antiepileptic effect.
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