中文摘要：

对青藤碱进行Mitsunobu甲基化反应，得到O-甲基青藤碱（2）；2经过酸性水解、硼氢化还原以及高碘酸钠氧化开环得到O-甲基青藤碱二醛（5）；在哌啶存在下对5进行羟醛缩合反应，区域选择性地闭环生成具有（＋）-C-normorphinan骨架的化合物（8S12S13R）-6，7-didehydro-3，4-dimethoxy-16-methyl-C-normorphinan-7-carboxaldehyde（7）；经过以上五步反应，7的总收率约35％．对7进行硼氢化还原得到化合物8；化合物8以醋酐进行酯化得到化合物9．化合物7以5％Pd／C为催化剂、1．01×10^5Pa下与氢气作用发生双键氢化反应，立体定向地得到化合物10，从化合物10出发获得化合物11和12．通过对化合物11的^1H NMR，^13C NMR，2D—NMR及NOESY等核磁共振分析确定化合物10，11和12具有7S绝对构型．

英文摘要：

Sinomenine （1） was O-methylated under Mitsunobu conditions to give O-methylsinomenine （2）, which was converted into O-methylsinomeninedialdehyde （5） through a procedure of acid hydrolysis, borohydride reduction and thereafter oxidation with NalO4. Ring-closure of 5 through Adol reaction in the presence of piperidine provided （8S, 12S,13R）-6,7-didehydro-3,4-dimethoxy- 16-methyl-C-normorphinan-7- carboxaldehyde （7） with （＋）-C-normorphinan skeleton in a total yield of about 35% from sinomenine. Thereby, compound 8 was prepared by the reduction of 7. And through esterification of 8 with acetic anhydride, compound 9 was synthesized. The hydrogenation of 7 with 5% Pd/C as catalyst under 1.01 × 10^5 Pa of hydrogen provided compound 10 stereo-directedly. Compounds 11 and 12 were obtained starting from 10. 10, 11 and 12 were determined as of 7S configuration based on the ^1H NMR,^13C NMR, 2D-NMR and NOESY analysis of compound 11.