以2-氯吡嗪和3-氨基-3-芳基丙酸为原料,经肼解、三氟乙酰化、闭环、氢化、缩合、脱保护等一系列反应合成了标题化合物,通过IR、1HNMR、13CNMR、MS对所得化合物的结构进行了表征。
A new compound 7- ( 3-amino-3-arylpropanoyl)-3- ( trifluoromethyl)-5,6, 7, 8-tetrahydro-[ 1,2, 4 ] triazolo [ 4, 3-α ] piperazine was synthesized from 2-chloropyrazine and 3-amino-3- arylpropionic acids through a series of reactions including hydrazinolysis, trifluoroacetylation, cyclization, hydrogenation, condensation and deprotection. The structure of the title compound was characterized by IR, ^1HNMR,^13CNMR and MS.