中文摘要：

目的：探讨按一定剂量规范补充维生素 D 对原发性高血压患者血压控制效果的影响。方法选取高血压患者100例，按自愿原则随机分为2组，每组50例。其中一组作为对照组，仅按照标准进行规范治疗；另一组作为实验组，在规范治疗的同时每日辅以25μg 的维生素 D 治疗。运用酶联免疫吸附测定（ELISA）检测各组血清25-羟基维生素 D[25（OH）D]水平。跟踪时间持续1年，其间监测各组血压控制情况，计算两组收缩压及舒张压的均值及变异系数，对两组结果进行比较。结果实验组血清25（OH）D 水平为（110．3±24．5）μg/L，收缩压为（144±16）mm Hg，收缩压的变异系数（CV1）为11．1％，舒张压（87±9）mm Hg，舒张压的变异系数（CV2）为10．3％；对照组血清25（OH）D 水平为（30．1±14．9）μg/L，收缩压为（145±27）mm Hg，CV1为18．6％，舒张压（89±10）mm Hg，CV2为12．4％。实验组与对照组比较，25（OH）D 水平、CV1的差异有统计学意义（P ＜0．01），舒张压及 CV2的差异无统计学意义（P ＞0．05）。结论规范治疗原发性高血压的同时定剂量补充维生素 D，有利于原发性高血压患者收缩压的控制，但对舒张压无明显影响。

英文摘要：

Objective To investigate the standard supplement of a certain dose of vitamin D for blood pressure control in pa-tients with essential hypertension.Methods 100 cases of patients with essential hypertension were randomly divided into 2 groups voluntarily,50 cases in each group.One group were set as control group,in which patients underwent a standard treatment.The other group was experimental group,in which 25 μg/d vitamin D was administrated in addition to standard treatment.Serum 25-hydroxyvitamin D[25 （OH）D]concentrations were measured by enzyme-linked immunosorbent assay（ELISA）and patients were followed up for one year to observe the situation of blood pressure controll.Mean and variable coefficient（CV）of systolic and dias-tolic blood pressure were calculated and compared between groups.Results In experiment group,the serum 25 （OH）D concentra-tion was （110.3±24.5）μg/L,systolic pressure was （144±16）mm Hg,variable coefficient of systolic pressure（CV1）was 11.1%, diastolic pressure was （87±9）mm Hg,variable coefficient of diastolic pressure（CV2）was 10.3%.While in control group,the 25 （OH）D concentration was （30.1±14.9）μg/L,systolic pressure was （145 ±26）mm Hg,CV1 was 17.9%,diastolic pressure was （87±10）mm Hg,CV2 was 12.4%.Serum 25（OH）D concentration and CV1 were statistically different between the two groups（P〈0.01）,CV2 was not statistically different（P 〉0.05）.Conclusion Administrate quantitative vitamin D in addition to standard treat-ment is helpful for systolic pressure control in patients with essential hypertension but is meaningless for diastolic pressure control.