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电阻抗成像监护小猪腹腔内出血的研究

ISSN号：1674-3474
期刊名称：《中华实用诊断与治疗杂志》
时间：0
分类：R318.6[医药卫生—生物医学工程;医药卫生—基础医学] R442.7[医药卫生—诊断学;医药卫生—临床医学]
作者机构：[1]第四军医大学唐都医院泌尿外科,西安市710038, [2]生物医学工程系
相关基金：国家自然科学基金（编号：50337020）

作者：张伟[1], 张鸿毅[1], 保庭毅[1], 杨增悦[1], 邱建新[1], 李玉梅[1], 帅万钧, 尤富生, 董秀珍

关键词：腹腔内出血, 生物电阻抗成像, 监护, Intraperitoneal bleeding, electrical impedance tomography, monitoring

中文摘要：

目的：观察电阻抗成像仪对闭合性腹腔内出血的监护结果。方法：采用体质量20～30kg、腹围与人近似的小猪为实验动物。将小猪取左侧卧位，从猪耳缘静脉注入肝素钠1．25万u后，在B超引导下置入穿刺针（G9）于肝脏表面，行“＋”形切割肝脏表面实质，造成肝脏出血。拔除穿刺针，形成1个闭合性腹腔内出血状态。然后用电阻抗成像仪进行监护，观察成像反应。在监护结束后对小猪解剖证实实验结果。结果：（1）电阻抗成像仪出现明显成像反应，目标区域出现颜色变化，并随着时间的延长颜色逐渐加深，出现颜色区域扩大。（2）解剖发现小猪腹腔内有大量不凝血液，在肝脏表面可见“＋”形切割创面，可见该切割创面仍渗血。结论：电阻抗成像用来监护腹腔内出血能产生明显的成像结果，故该技术可以用来进行人体出血监护。

英文摘要：

Objective To observe the result of electrical impedance tomography in monitoring closed intraperitoneal bleeding. Methods The piglets weighing from 20 to 30 kg with the abdominal perimeter as human＇s were chosen as our experimental objects. In left lateral position, 12 500 u heparin was injected into the ear edge vein, and a transfixion pin （G9） was placed onto the surface of liver under the guidance of ultrasound. Liver bleeding was made by a ＂＋＂ incision on the hepatic tissue. The transfixion pin was withdrawn, and the piglet was in a state of closed intraperitoneal bleeding. Electrical impedance tomography was applied to monitor images change. The results were confirmed by anatomy. Results （1） Significant images changes were observed by electrical impedance tomography. The target area had color change, which became deeper and larger in area with the time. （2） A lot of non-coagulant blood in abdominal cavity was found in dissection and the ＂＋＂ incision was found bleeding in the surface of liver. Conclusion It suggests that electrical impedance tomography can generate an evident image change when monitoring the bleeding in abdominal cavity. This new technique could be used to monitor bleeding in human body.

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