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可诱导核酸交联剂的研究进展
  • 期刊名称：化学进展， 2007, 19, 1999
  • 时间：0
  • 分类：Q52[生物学—生物化学] Q503[生物学—生物化学]
  • 作者机构：[1]武汉大学化学与分子科学学院,武汉430072
  • 相关基金：国家自然科学基金（No.20672084）、国家杰出青年基金（No.20425206）和高等学校科技创新工程重大项目培育资金项目（No.706040）资助
  • 相关项目：生物有机化学
关键词： DNA, 交联, 诱导, DNA , cross-linking, induction
中文摘要：

如何选择性地破坏癌细胞DNA链结构的药物，一直是研究的热点，可诱导核酸交联剂在增加药物靶标选择性方面有很多优点。利用氧化、还原或光诱导产生的DNA交联作用，在临床治疗中具有重要意义。本文就可诱导核酸交联剂的最新研究进展做了评述。

英文摘要：

Selectively destroy the DNA of the tumor cells by induction has been arosed much attention for medicinal application. Inducible DNA cross-linking agents have provided a promising method for these researches. The selectivities of the targets induced by various methods, such as oxidation, reduction and light-induction to cross-link DNA, hold great importance on clinic therapy. The most recent advances on inducible DNA cross-linking agents are reviewed in this paper.

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可诱导的核酸交联剂作为潜在抗肿瘤药物的基础研究
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