大量研究已证实生物活性肽是一类对机体有许多重要生理功能的物质,对拥有巨大表面积的肠黏膜有着重要的免疫调节作用。本文首先概括生物活性肽的研究现状;在从肠黏膜系统组成及其免疫机制的角度,结合前期的研究工作,就生物活性肽对SIgA、Th细胞及其细胞因子以及免疫信号途径影响的相关研究进行介绍。同时根据国外学者近期研究的成果,提出研究生物活性肽与机体免疫作用关系的发展趋势。
Numerous studies have reported that bioactive peptides have many physiological functions to human including immune regulation on gut mucosa with tremendous surface area. Current research progress of bioactive peptides is reviewed here. Effects of bioactive peptides on SIgA, Th cells, cytokines and immune signaling pathways are discussed on the basis of structures and immune mechanisms of gut mucosa. The future development prospects of bioactive peptides are proposed.