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中文摘要：
转化生长因子β（transforming growth factor β，TGF-β）是一类多功能的细胞因子，参与调控胚胎发育、创伤愈合、细胞增殖和分化等过程。此外，在多种肝病的发病机制中，TGF-β也发挥着调控作用。肝脏内多种细胞都能合成分泌TGF-β，并表达TGF-β的相关受体，通过不同的信号通路在肝病进程中起到至关重要的作用。该文将对TGF-β信号通路在肝病发生发展中的作用及以其为靶点的肝病治疗药物的研究进展作一综述。
英文摘要：
Transforming growth factor β（ TGF-β ） exerts multifunctional roles in the processes of embryonic development, wound healing, cell proliferation and differentiation. Moreover, TGF-β is also involved in the pathogenesis and development of various liver diseases. A variety of liver cells are considered to secrete TGF-β ligands and express related receptors, and consequently play a crucial role in the progression of liver disease via different signal pathways. In this paper, the role of TGF-β signaling pathway in liver diseases and targeting the TGF-β signaling in the treatment of liver diseases are reviewed.
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