中文摘要：

背景与目的基质金属蛋白酶7（matrixmetalloproteinase7，MMP-7）又称基质溶解素，是MMPs家族成员之一，本研究旨在检测MMP-7在肺癌患者和正常人外周血血浆中的蛋白水平，并探讨其临床意义。方法采用酶联接免疫吸附试验（enzyme，linkedimmunosorbnentassay，ELISA）检测114例肺癌患者和100名正常人外周血血浆标本中的MMP-7浓度。结果肺癌患者外周血血浆中的MMP-7蛋白浓度（n=114,median=0．72ng／mL）明显高于正常人外周血血浆中的MMP-7蛋白浓度（n=100，median=0．30ng／mL，P〈0．001），当cutoff值为0．56ng／mL时，MMP-7检测肺癌的敏感性为62．3％，特异性为76．0％。但是，肺癌患者外周血血浆中MMP-7的蛋白水平与患者的年龄、性别、吸烟史、肿瘤大小、病理类型、淋巴结转移及分期均无关（P〉0．05）。结论外周血血浆中MMP-7可以作为辅助肺癌诊断的一种肿瘤标志物，但其与肺癌的各项临床参数之间无明显联系，需要进一步扩大样本进行分析。

英文摘要：

Background and objective Matrix metalloproteinase 7 （MMP-7）, also known as matrilysin, is a mem- ber of the MMP family. The objectives of this study were to test MMP-7 protein levels in the peripheral blood of lung cancer patients and healthy control subjects and to determine their corresponding clinical significance. Methods Peripheral blood samples were obtained from 114 lung cancer patients and 100 healthy control subjects. MMP-7 protein levels in the plasma were measured by enzyme-linked immunosorbent assay. Results The plasma protein levels of MMP-7 in lung cancer patients （median=0.72 ng/mL） were significantly higher than those in healthy control subjects （median=0.30 ng/mL）（P〈0.001）. When the cutoff of MMP-7 protein level was set at 0.56 ng/mL, the sensitivity and specificity of detecting lung cancer were 62.3% and 76.0%, respectively. However, the lung cancer patients and healthy control subjects did not statistically differ in age, sex, smoking status, tumor size, pathological classification, as well as lymphatic metastasis and stage （P〉0.05）. Conclusion The plasma protein levels of MMP-7 increase in the peripheral blood of lung cancer patients. Peripheral blood MMP-7 can be used as a tumor marker for detecting lung cancer. The fact that no significant correlation between the protein levels of MMP-7 and lung cancer clinical parameters was observed in this study warrants further analysis in larger samples.