中文摘要：

目的 探讨鼻咽癌组织中特异性成骨细胞因子-2（periostin）与整合素（integrin）蛋白表达的相关性.方法 采用免疫组织化学方法检测66例鼻咽癌组织和30例正常鼻咽黏膜组织标本中periostin与integrin蛋白表达水平,分析periostin与鼻咽癌临床病理因素的关系及其与integrin表达的相关性.结果 periostin在正常鼻咽黏膜及鼻咽癌组织间质中表达,integrin则主要在细胞胞膜上表达,两者在鼻咽癌组织中表达的强度均明显高于正常鼻咽黏膜.统计学分析显示periostin与鼻咽癌的临床分期、组织学类型及转移有关,Spearman相关统计学分析结果表明鼻咽癌组织中periostin与integrin表达呈正相关（r=0.875,P=0.000）.结论 periostin蛋白表达与NPC的侵袭和转移相关,在鼻咽癌组织的表达与integrin呈正相关,提示periostin可能通过与膜上integrin受体结合发挥作用.联合检测二者的表达可为鼻咽癌的诊断和治疗提供参考依据.

英文摘要：

Objective To study the correlation between the expression of periostin and integrin protein in nasopha- ryngeal carcinoma. Methods The expression of pefiostin and integrin protein were detected by immunohistochemistry in 66 cases of NPC and 30 cases of normal nasopharyngeal mueosa （NNM） ,statistics analysis were used to evaluate the rela- tionships between pefiostin expression and clinicopathological factors, and the correlation of periostin and integrin. Results Periostin expression can be observed in the stroma of NPC and NNM, integrin expression usually be observed on the cell membrane. The two proteins over-expression was both frequently observed in the stroma of NPC compared with the stroma of NNM. Periostin over-expression was significantly associated with advanced clinical stage, histological type and metastasis in NPC. Conclusion The expression of periostin was associated with the invasion and metastasis of NPC, and positively correlated with integrin expression in NPC, which suggested that periostin carry out its function by combined with membrane receptor-integrin. Detection periostin expression combine with integrin expression can provide reference for the diagnosis and treatment of NPC.