中文摘要：

利用扩散加权磁共振成像技术研究了链脲佐菌素（STZ）诱导大鼠糖尿病4周时视神经的病理改变。测量平行和垂直于视神经方向上的水质子的表观扩散系数，分别用ADC∥和ADC⊥来表示。初步结果显示模型组左右侧视神经ADC∥没有出现一致的改变，而ADC⊥都有下降的趋势，但没有达到统计显著性。该结果提示STZ诱导4周后扩散成像测量参数ADC⊥的改变可能反映了糖尿病引起的视神经轴突损伤。

英文摘要：

Type-I diabetes was induced in rats by a single injection of streptozotocin （STZ）. Directional diffusion-weighted imaging on the optic nerves were performed one month later to monitor the early optic neuropathy （e. g. , axonal injury and myelin sheaths damage） induced by diabetes. Water diffusivities parallel and perpendicular to the axonal tracts were measured by apparent diffusion coefficients ADC∥ and ADC⊥, respectively. Compared to the control animals, the STZ-treated animals showed a trend of reduced ADC⊥ in bilateral optic nerves, but less consistent changes in ADC∥.