中文摘要：

转移消失蛋白（missing in metastasis,MIM）是一种重要的胞内膜调控蛋白,属于inverse BAR（I-BAR）家族成员,能结合细胞膜并在细胞极化、运动和内吞作用等过程中发挥调节功能,其表达异常与多种疾病尤其是肿瘤发生或转移相关,在神经系统、循环系统和生殖泌尿系统中也有一定作用.MIM蛋白的生物学功能包括调节肌动蛋白细胞骨架、与皮动蛋白等其他蛋白相互作用、参与细胞信号通路调控、改变细胞膜形态并促进细胞极化等,在结构上表现出典型I-BAR家族成员特征,借助其N端的I-BAR区域自聚合形成二聚体,促使细胞膜形成伪足状突起,甚至可以调控人造磷脂囊泡,但二聚体的形成也可被靶向的多肽等抑制剂阻断.除作用于蛋白I-BAR,RPTP结合域的特异性多肽外,MIM也可被RNAi干涉,在肿瘤生物治疗领域具有开发潜力.本文回顾了MIM蛋白相关医学研究进展,综述了MIM蛋白已知的生物功能,分析了MIM蛋白靶向治疗及其他应用前景,并提出了可能的研究新方向、新思路.

英文摘要：

Missing-in-metastasis （MIM, also known as metastasis suppressor 1） belongs to the inverse BAR （I-BAR） family of intracellular membrane remodeling proteins. Structurally, MIM displays typical I-BAR family protein features including the ability to dimerize through its N-terminal I-BAR domain, which can be arrested by specific peptide inhibitors. It also induces filopodia-like membrane protrusions, and can reform artificial phospholipid vesicles. MIM binds to the inner plasma membrane and participates in multiple cellular activities including cell polarization, mobility, actin cytoskeleton regulation, protein interaction, cellular signal pathway facilitation, membrane shaping, and endocytosis. These activities are mostly performed in the nervous, circulatory, urinary, and reproductive systems. MIM abnormalities occur in a number of human diseases, especially those involving tumor genesis and metastasis. As well as MIM-specific peptides, RNA interference can be used to inhibit MIM expression. These molecular tools have the potential to be used in future bio-pharmaceutical developments. In this review, advances in MIM-related research are summarized, and the prospect of MIM targeting therapy and other MIM-based applications are introduced.