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树状大分子包裹金纳米颗粒的制备、尺寸控制和稳定性研究
  • 期刊名称：高分子通报
  • 时间：0
  • 页码：78-84
  • 分类：TB381[一般工业技术—材料科学与工程]
  • 作者机构：[1]东华大学化学化工与生物工程学院
  • 相关基金：上海高校特聘教授(东方学者)岗位计划资助;; 国家重点基础研究发展计划资助(2007CB936000);; 国家自然科学基金面上项目(20974019)资助;; 东华大学校基金(2008,105100044048)资助
  • 相关项目：多功能树状大分子包裹的纳米金颗粒作为平台用于癌细胞的CT成像研究
作者： 郭睿|沈明武|潘敏洁|史向阳|
关键词： 金纳米颗粒, 树状大分子, 稳定性, Gold nanoparticles, Dendrimer, Stability
中文摘要：

作者以氨基封端的第五代聚酰胺胺(PAMAM)树状大分子为模板,借助静电相互作用将氯金酸盐吸引进入树状大分子内部,再由外加还原剂硼氢化钠将金盐原位还原,得到了树状大分子包裹的金纳米颗粒(Dendrimer-Entrapped Gold Nanoparticles,Au DENPs),并应用紫外、表面电势法、透射电镜和能量色散谱等手段对其结构进行表征。通过改变氯金酸与树状大分子的投料比,平均尺寸在1.9~2.8nm的Au DENPs被成功制备。制得的Au DENPs不仅在水、PBS缓冲液以及生理环境下稳定存在,还在较宽的pH(pH=5~8)与温度(4~50℃)范围内稳定,为其应用于生物医学领域提供了可能。

英文摘要：

In this paper,dendrimer-entrapped gold nanoparticles(Au DENPs) were prepared by using amine-terminated generation 5 poly(amidoamine)(PAMAM) dendrimers as templates to complex gold salt via electrostatic interactions,and sodium borohydride(NaBH_4) as a reducing agent.UV-vis absorption spectra,zeta potential measurements,transmission electron microscopy(TEM) and energy-dispersive X-ray spectroscopy(EDS) were used to characterize these nanoparticles in aqueous state and in dry state.By varying the molar ratio ...

同期刊论文项目
多功能树状大分子包裹的纳米金颗粒作为平台用于癌细胞的CT成像研究
期刊论文 30 会议论文 10
　人工纳米生物机器构筑与生物医学应用的基础研究
期刊论文 40
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