中文摘要：

目的：研究威灵仙注射液关节腔离子导入对OA的软骨和滑膜组织形态和软骨MMP-1细胞凋亡的影响。方法：新西兰兔40只，除保留10只作为正常组外，余均采用木瓜蛋白酶关节腔注射复制OA模型。造模4周后，根据模型动物关节肿胀度随机分为模型组、Wlx组、Qand组。实验结束时，取模型动物关节软骨和滑膜进行病理形态学检查，同时观察软骨细胞凋亡情况。结果：威灵仙关节腔离子导入能明显降低模型动物关节软骨和滑膜的病理总积分，同时亦能明显降低软骨 MMP-1细胞的阳性表达率。结论：威灵仙关节腔离子导入可能具有抑制骨关节炎的软骨退行性改变的作用，能够延缓OA的炎症进程。

英文摘要：

Objective：To study effects of Clematis chinensis injection on OA cartilage and synovial membrane tissue morphology and apoptosis of MMP-1 cell with articular cavity iontophoresis. Methods：40 New Zealand rabbits, except 10 rabbits as normal group, the others were used to replicate OA model by papain intra-articular injection. After 4 weeks modeling, according to the degree of joint swelling, model animals were randomly divided into model group, Wlx group, Qand group. At the end of the experiment, examinated pathological total points of articular cartilage and synovium membrane, the cartilage cell apoptosis was observed. Results：Clematis articular iontophoresis can significantly reduce articular cartilage and synovial pathological score of model animals, but also can significantly reduce the positive expression rate of MMP-1 cell of cartilage. Conclusion： Clematis articular iontophoresis may inhibit osteoarthritis cartilage degeneration, can slow down the inflammatory process of OA.