中文摘要：

目的探讨妊娠期糖尿病（GDM）患者血清雌二醇水平与胰岛素抵抗的相关性。方法采集妊娠晚期107例正常孕妇（A组）和103例GDM孕妇（B组）外周血。用ELISA法检测血清17β-雌二醇水平,并检测空腹血糖（FBG）及空腹胰岛素（FIns）水平。应用稳态模式评估法计算胰岛素抵抗指数（HOMA-IR）和胰岛素敏感指数（HOMA-ISI）,分析血清17β-雌二醇表达与HOMA-IR、HOMA-ISI的相关性。结果与A组相比,B组血清17β-雌二醇、FBG和FIns水平以及HOMA-IR升高（P〈0.05或P〈0.01）,而HOMA-ISI降低（P〈0.01）。血清17β-雌二醇水平与HOMA-IR呈正相关（r=0.787,P〈0.01）,而与HOMA-ISI呈负相关（r=-0.765,P〈0.01）。结论雌激素可能参与了GDM的病理生理过程;血清雌激素水平升高导致的胰岛素抵抗可能是GDM的发病机制之一。

英文摘要：

Objective To investigate the correlation between serum level of estrogen and insulin resistance（IR） in the patients with gestational diabetes mellitus （GDM）. Methods The peripheral blood was collected from 107 normal pregnant women（group A） and 103 pregnant women with GDM （group B）. Serum 17β-estradiol was detected by ELISA,and the levels of fasting blood glucose（FBG） and fasting insulin（Fins） were measured as well. The insulin resistance index（HOMA-IR） and insulin sensitivity index（HOMA-ISI） were calculated by homeostasis model assessment （HOMA）. The correlation between 17β-estradiol level and HOMA-IR, HOMA-ISI was analyzed. Results Compared with group A, HOMA-IR and serum levels of 17β-estradiol, FBG and Fins were increased（P〈0. 05 or P〈0. 01）,while HOMA-ISI was decreased in group B（P（0. 01）. Serum level of 17β-estradiol was positively correlated with HOMA-IR（r=0. 787,P〈0. 01） and negatively correlated with HOMA-ISI （r=-0. 765, P〈0. 01）. Conclusion Estrogen may be involved in the development of GDM. That elevated serum estrogen induces insulin resistance may be one of the underlying mechanisms for GDM.