中文摘要：

目的将在猪的冠的 neointimal 形成上检验蓬莪术必需品 component-eluting stent (ZES ) 的效果。方法 ZES， sirolimus-eluting stents (SES ) ，和赤裸的金属 stents (BMS ) 随机在 36 头伤害汽球的猪在三个不同主要 epicardial 容器被植入。冠的 angiography，光连贯断层摄影术，和 histomorphological 分析被用来决定 antihyperplasia 效果。结果 ZES 和 SES 有一条显著地更大的腔直径和区域，并且与与 BMS 植入的动脉相比在 30 和 90 天在动脉减少了狭窄的直径和区域(P < 0.01 ) 。Histomorphometric 分析显示出中等煽动性的回答，例如在有与 ZES 相比的 SES 的一些动脉的 mononuclear 房间，淋巴细胞，和 multinucleated 巨人房间的渗入(P < 0.05 ) 。损害分数不在在 30 和 90 天的三个组之中是不同的。在 SES 组的 endothelialization 分数是 2.69 ?? 嶑鞬? 綵錿? 1 楲污爠 ' 虨禈 N 楶祴 ? 湡 ? 慭? 汰祡愠 ? 浩潰瑲湡 ? 潲敬椠 ? 浥牢潹楮 ? 浩汰湡慴楴湯

英文摘要：

Objective： To examine the effect of the zedoary essential component-eluting stent （ZES） on a porcine coronary neointimal formation. Methods： ZES, sirolimus-eluting stents （SES）, and bare metal stents （BMS） were randomly implanted in three different major epicardial vessels in 36 balloon-injured pigs. Coronary angiography, optical coherence tomography, and histomorphological analysis were used to determine antihyperpiasia effects. Results： ZES and SES had a significantly larger lumen diameter and area, and reduced diameter and area of stenosis in arteries at 30 and 90 days compared with arteries implanted with BMS （P〈0.01）. Histomorphometric analysis showed moderate inflammatory responses, such as infiltration of mononuclear cells, lymphocytes, and multinucleated giant cells in some arteries with SES compared with ZES （P〈0.05）. Injury scores were not different among the three groups at 30 and 90 days. The endothelialization score in the SES group was 2.69± 0.42 at 30 days and 2.83 ± 0.39 at 90 days compared with the ZES and BMS groups （both were 3.00 ± 0.00 at either 30 or 90 days, P〈0.05）. Well developed endotheiium was observed in the ZES group, while incomplete endothelium and inflammatory cells were observed with stent struts partly naked at the vessel lumen in the SES group. Conclusion： The ZES inhibits neointimal hyperplasia with good endothelia coverage in the porcine balloon injury coronary model.