中文摘要：

围手术期免疫反应及其炎症通路被认为是引起围手术期器官损伤、术后免疫功能不全及相关疾病的重要因素.麻醉药物、围手术期常用药物、血液制品等均可影响围手术期免疫反应.例如,常用麻醉和阿片类药物可抑制固有和适应性免疫,抑制自然杀伤细胞的功能,可能影响其对肿瘤监视功能.随着转录组学、质谱流式细胞技术等研究手段的不断应用,学界对围手术期免疫反应将会建立更趋清晰的认识与理解.本文就近年来该领域的研究进展作一综述.

英文摘要：

Perioperative immune response and inflammatory pathways are considered as important factors in organ damage caused during the perioperative period, postoperative immune dysfunction and related diseases. Anesthetics, other agents usually applied perioperatively, and blood transfusion can affect the immune response preoperatively. For example, commonly used anesthetics and opioids can inhibit innate and adaptive immunity, inhibiting the function of natural killer ceils, and thus influence their ability on tumor surveillance. With the conti-nuous application of research methods such as transcriptomics and mass cytometry, there will be a clearer under-standing of perioperative immune response.