中文摘要：

趋化因子（chemokines）是一类可调节免疫反应的小分子家族。趋化因子及其受体信号与肿瘤的进展、转移和血管生成密切相关。近年的研究发现,趋化因子及其受体信号通路广泛参与非小细胞肺癌的血管生成、侵袭及转移;一些趋化因子及其受体可作为非小细胞肺癌的预后评价指标及治疗的潜在靶标。

英文摘要：

Chemokines are a small molecules family that adjusts immune responses. The signal of chemo- kines and their receptors are significantly associated to tumor progression, metastasis and angiogenesis. In recent years, the studies have found that chemokines and their receptors signaling pathways extensively par- ticipate in non-small cell lung cancer angiogenesis, invasion and metastasis. Some of chemokines and their receptors can be used as prognostic biomarker and potential target for NSCLC therapy.