药物代谢组学通过分析比较药物干预前、后生物体代谢谱,评价和预测药物的疗效、毒性及药动学特征,为临床个体化用药和精准治疗提供了新的思路与策略。从药物代谢组学的应用及其所呈现出的优势与面临的挑战和对策等方面,对目前药物代谢组学研究进展作一综述。
Phannacometabolomics aims to estimate and predict the efficacies, toxicities and pharmacokinetics of drugs by analyzing and comparing the metabolic spectra before and after drug interventions, providing new thoughts and strategies for clinical individualized medication and precise treatment. In this paper, the current research progress in pharmacometabolomics was reviewed from the aspects of applications, superiorities, challenges to confront and countermeasures.