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Highly lipophilic 3-epi-betulinic acid derivatives as potent and selective TGR5 agonists with improved cellular efficacy
  • ISSN号：1671-4083
  • 期刊名称：《中国药理学报：英文版》
  • 分类：Q57[生物学—生物化学] O636.1[理学—高分子化学;理学—化学]
  • 作者机构：[1]State Key Laboratory of Drug Research, CAS Key Laboratory of Receptor Research, the National Center for Drug Screening, ShanghaiInstitute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
  • 相关基金：Acknowledgements This work was supported by grants from the National Science and Technology Major Projects for Major New Drugs Innovation and Development （No 2012ZX09304011, 2013ZX09507001, and 2012ZX09301001-005）, National Basic Research Program of China （973 Program） （No 2014CB541906） and the National Natural Science Foundation of China （No 30725049 and 81202341）,
作者： Xiao-yin WANG Shu-yong ZHANG Jing LI Hua-nan LIU Xin XIE Fa-jun NAN[1]
关键词： 衍生物, 激动剂, 细胞系, 亲脂性, 桦木, 胰高血糖素样肽-1, HEK293, GLP-1, TGR5, activator, betulinic acid derivatives, GLP-1, lipophilic, structure modifications
中文摘要：

E-mail：xxie@simm.ac.cn E-mail：fjnan@simm.ac.cn

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期刊信息
  • 《中国药理学报：英文版》
  • 中国科技核心期刊
  • 主管单位:中国科学技术协会
  • 主办单位:中科院上海药物研究所
  • 主编：丁光生
  • 地址：上海市太原路294号31号楼
  • 邮编：200031
  • 邮箱：
  • 电话：021-54922821 54922822
  • 国际标准刊号：ISSN：1671-4083
  • 国内统一刊号：ISSN：31-1347/R
  • 邮发代号:4-295
  • 获奖情况:
  • 1992、1996年两届全国优秀科技期刊一等奖,1992、1996、1997年中国科协、中科院以及上海市优...,首届国家期刊奖、2000年中科院优秀期刊评比特别奖
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  • 被引量:1239