中文摘要：

心脑血管疾病严重威胁人类健康，有效预防和治疗心脑血管疾病是当代医学研究的重点。非对称性二甲基精氨酸（asymmetric dimethylarginine，ADMA）和对称性二甲基精氨酸（symmetric dimethylarginine，SDMA）是心脑血管疾病或心脑血管事件独立的预测因子。丙氨酸－乙醛酸转氨酶2（al-anine-glyoxylate aminotransferase 2，AGXT2）是内源性 ADMA的水解酶之一，其表达缺失或活性降低可影响体内 ADMA的水平，而AGXT2的多个单核苷酸多态性与体内SDMA的水平明显相关。深入研究AGXT2在心脑血管疾病发生发展中的作用对以AGXT2为靶点开发新型心脑血管保护药物具有重要意义。该文就AGXT2参与 ADMA 的代谢及其与心脑血管疾病的最新研究进展进行综述。

英文摘要：

Cardiovascular and cerebrovascular diseases have be-come a great health threat.Increasing evidence has shown that both asymmetric dimethylarginine （ADMA）and symmetric dim-ethylarginine （SDMA）play important and independent roles in the development of cardiovascular and cerebrovascular diseases as well as in the prediction of cardiovascular and cerebrovascular events.Alanine-glyoxylate aminotransferase 2 （AGXT2 ）is re-cently observed to be involved in ADMA metabolism.Deficiency in the expression and activity of AGXT2 may thus play a role in＆nbsp;the development of cardiovascular and cerebrovascular diseases by affecting ADMA levels in vivo.Several single-nucleotide poly-morphisms at AGXT2 locus are observed to be associated with plasma SDMA level.This review summarizes recent advances in AGXT2 and its role in ADMA metabolism and the clinical rele-vance.