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中文摘要：
【目的】研究不同碘营养水平对子代大鼠小脑神经细胞形态发育的影响。【方法】应用MIAS-2000型图像分析系统对子代大鼠小脑各层的神经细胞进行形态学测量。【结果】低碘组（LI）14d龄外颗粒层（EGL）厚度明显大于正常碘组（NI），14d和28d龄分子层厚度、Purkinje细胞截面积、颗粒细胞密度均明显小于NI组，且有统计学差异；各高碘组（HI）与NI组比较，随碘摄入量的增多，14d和28d龄分子层厚度、Purkinje细胞截面积、颗粒细胞密度有降低的趋势，尤其是50倍和100倍高碘组（50HI和100HI）颗粒细胞密度明显小于NI组，且有统计学差异。【结论】低碘和严重高碘可以影响小脑EGL细胞向分子层和内颗粒层神经细胞分化和迁移，同时影响了Purkinje细胞和颗粒细胞的正常发育；但轻度高碘组未见明显变化，提示：大鼠对高碘的耐受性要强于低碘。
英文摘要：
[Objective] To study the morphological alterations of cerebellum in off- spring rat subjected to different leve] of dietary iodine supply. [Methods] The morphometry was performed to nerve cells in all layers of cerebellar cortex using computed MIAS-2000 Image Analysis System. [Results] The external granular layer （EGL） in LI group was significantly thicker than that in NI group in 14 d rats. The thickness of molecular layer, the section areas of Purkinje cells and the cellular density of internal granular layer in LI group were significantly smaller than the NI group in both 14 d and 28 d rats. All changes above in HI groups showed decrease tendency with increase of iodine supply, especially in very high io- dine groups （50 HI and 100 HI） were significantly lower than the NI group. [Conclusions] Iodine deficiency and severe iodine excess can affect the immigration and differentiation of EGL to molecular layer and internal granular layer, and also retarded other neurocyte development. Our results indicated that rats had better tolerance to iodine excess than iodine deficiency.
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