杆状病毒在其生命周期中形成了两种不同的病毒类型:出芽型病毒粒子(budded virus,BV)和包埋型病毒粒子(occlusion derived virus,ODV),其中ODV负责口服感染,而BV负责系统感染。它们又分别应用于不同的生物技术领域,如BV可用于杆状病毒表达载体,而富含ODV的多角体主要用于生物防治。近年来蛋白质组学的研究进展对BV和ODV的产生机理有了新的认识,现主要总结这方面的研究结果。
Baculovirus produces two phenotypes of progeny virions during its life cycle: budded virus(BV) and occlusion derived virus(ODV). BV is responsible for systematic infection in the host and has been used widely as foreign gene expression vector, while ODV is responsible for initiating oral infection and has been used for biological control. Recently, the proteomics researches on BV and ODV have revealed the structural similarity and differences between the two phenotypes. In this review, we summarize the relationship between the structure of BV and ODV and their functions of oral and systematic infection, as well as the impacts on future research and development.