中文摘要：

壳聚糖（chitosan，CS）是甲壳素脱乙酰化的产物，是由葡萄糖结构单元组成的直链多糖。CS作为一种带正电荷的天然多糖，本身具有无毒、无刺激性、无致敏性、无致突变的性质，降解产物为低分子壳寡糖和葡萄糖胺，具有良好的生物相容性和生物降解性。CS本身具有的特性，引起了人们的极大兴趣，在过去的三十年中，其在农业、工业和医药等领域中的应用发展迅速。在药物制剂方面，

英文摘要：

The chitosan nanosphere is formed by the ion gel and charaetered by TEM. The encapsulation efficiency and controlled release of chitosan nanoparticles for BSA are studied. The result suggests that the high encapsulation efifiency and loading of BSA reach 86% and 49% ,the BSA encapsulation efficiency and the BSA loading are affected by the initial CS concentration and the initial BSA concentration, the higher the initial CS concentration, the higher the BSA encapsulation efficiency and the BSA loading. However, it shows opposite trend when the initial BSA concentration increase. The BSA loading increase, but the encapsulation efficiency decrease. The TPP concentration has httle influence on BSA encapsulation efficiency. The behavior of ehitosan nanospheres for BSA in vitro release revealed a controlled and continuous release of the entrapped protein after 12 hours and released 30% of the BSA loading within 3 hours.