中文摘要：

目的对传统的纯钛帽改良后植入兔颅骨,建立新的种植体表面处理研究的动物模型。方法运用数控机床对纯钛板进行机械加工,压制中空半球形钛帽,底部添加自攻性螺纹,顶部添加两个环形小孔。48个纯钛帽植入12只新西兰兔颅骨。选取观察时间点为2周、4周,6周。通过大体标本和牙科微型CT观察纯钛帽植入的稳定性,制作带金属不脱钙硬组织切片,观察纯钛帽植入兔颅骨的动物实验模型骨组织效应。结果手术过程中植入共48个纯钛帽,其中2个松动,松动率为4.17%;植入2、4、6周取材时,48个标本无松动,脱落。牙科微型CT结果显示,纯钛帽能够稳定在兔颅骨上。带金属不脱钙硬组织切片显示,新旧骨组织形成明显界限,周围骨组织长入纯钛帽底部的螺纹,嵌合良好。结论改良自攻性纯钛帽制作加工相对传统的钛帽工艺简单,稳定性良好,减少辅助固定装置,减少手术创伤,简化操作步骤,提高实验效率,可以用于研究种植体表面处理方式的动物模型。

英文摘要：

Objective To establish the experimental model of the optimized pure titanium dome with self-tapping threads on rabbit calvarial bone surface. Methods The prefabricated pure titanium domes, with inner empty hemispherical shape, was performed by special precision machine tool, added some self-tapping threads on the root of the domes and two circular small holes on the top （diameter 0.8 mm）. All the inner surface of the pure titanium domes had the same basic form and topography. Fourty-eight pure titanium domes were placed in calvarial bone surface of twelve healthy New Zealand rabbits. The animals were sacrificed at 2nd week, 4th week and 6 th week after the placement of pure titanium dome. The stability of the pure titanium domes were investigated by general observation and Micro CT scanning. Various histomorphometric observations were performed in the central of the undecalcified sections. Results The stability of the forty-eight pure titanium domes were excellent at 2nd week, 4 th week and 6th week when the rabbits were scarified. Only 2 were less fixable at the initial placing process with loose rate 4.17% in general observation. The Micro CT showed that all the pure titanium domes were fixed well on rabbit calvarial bone space. The results of the undecalcified sections showed that the bone tissue around the bottom of the pure titanium dome grew into the thread, which indicated the stability of the domes in different times. The pure titanium domes with self-tapping thread was helpful for distinction of new bone tissue growth. Conclusion The design of the pure titanium dome with self-trapping screw is less complicate than the traditional ones. The self-trapping screws do help to increase the stability of the pure titanium domes.The application of the pure domes with self-trapping screws on rabbit calvarial bone surface reduces the surgical trauma and simplify the operation steps, improve the efficiency, which was more objective and reliable to reflect implant biocompatibility and bone response. The optimized