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脂蛋白磷脂酶A2活性与动脉粥样硬化斑块稳定性的相关性

ISSN号：1000-1832
期刊名称：《东北师大学报：自然科学版》
时间：0
分类：R73[医药卫生—肿瘤;医药卫生—临床医学]
作者机构：茂名市人民医院心内一科,广东茂名525000
相关基金：茂名市科技计划项目（2012009）

关键词：脂蛋白磷脂酶A2活性, 动脉粥样硬化斑块, 稳定性, 超敏C反应蛋白, 五聚素3, Lp - PLA2 , atherosclerotic plaque , stability, hs - CRP, PTX3

中文摘要：

目的研究脂蛋白磷脂酶A2活性与动脉粥样硬化斑块稳定性的相关性,探讨脂蛋白磷脂酶A2活性是否是易损斑块的危险因子。方法根据颈动脉彩超或冠脉造影检出斑块,冠脉造影检出冠脉闭塞,将研究对象分为4组：无斑块组、稳定斑块组、不稳定斑块组和破裂斑块组,分别检测并对比分析四组脂蛋白磷脂酶A2活性（Lp-PLA2）、超敏C反应蛋白（hsCRP）、低密度脂蛋白（LDLC）、五聚素3（PTX3）等。结果四组间Lp-PLA2、LDLC、hs-CRP、PTX3水平间差异具有统计学意义（P〈0.05）,稳定斑块组、不稳定斑块组和破裂斑块组的Lp-PLA2、LDLC、hs-CRP、PTX3水平均显著高于无斑块组,不稳定斑块组和破裂斑块组的Lp-PLA2、LDLC、PTX3水平均显著高于稳定斑块组,破裂斑块组的Lp-PLA2、LDLC、hs-CRP、PTX3水平均显著高于不稳定斑块组;Logistic回归分析最后筛选出Lp-PLA2、LDLC、hs-CRP、PTX3为斑块稳定的影响因素（P〈0.05）,且均为危险因素。结论脂蛋白磷脂酶A2活性与动脉粥样硬化斑块稳定性紧密相关,且为危险因素,对斑块稳定存在一定程度的预测作用。

英文摘要：

Objective To study the relationship between lipoprotein phospholipase A2 activity and the stability of atherosclerotic plaques, and to explore whether lipoprotein phosphatase A2 activity is a risk factor for vulnerable plaques. Methods The coronary arteries were detected by carotid ultrasonography or coronary angiography. Coronary occlusion was performed. The subjects were divided into four groups ： no plaque group, stable plaque group, unstable plaque group and ruptured plaque （ Lp - PLA2）, hypersensitive C - reactive protein （ hs - CRP） ,low density lipoprotein （LDLC） and pentosan 3 （ PTX3 ） were detected and compared. Results The differences of Lp - PLA2, LDLC, hs - CRP and PTX3 between the four groups were statistically significant （ P 〈 0.05 ）, Lp - PLA2, LDLC, Lp - PLA2, LDL, Hs - CRP and PTX3 were significantly higher than those in the non - plaque group, and the levels of Lp - PLA2, LD- LC and PTX3 in the unstable plaque group and the ruptured plaque group were significantly higher than those in the stable plaque group, （P 〈 0.05 ）. The expression of Lp - PLA2, LDLC, hs - CRP and PTX3 were significantly higher than those of the untreated plaque group （ P 〈 0.05 ）. Logistic regression analysis showed that Lp - PLA2, LDLC, hs - And are risk factors. Conclusion The activity of lipoprotein phospholipase A2 is closely related to the stability of atherosclerotic plaque, and it is a risk factor,which has a certain degree of predictive effect on plaque stability.

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