中文摘要：

目的探讨汉人酗酒与动脉粥样硬化（As）之间的关系。方法（1）随机选择心绞痛、心肌梗死、心肌纤维化、脑梗死、脑溢血等As相关疾病患者165例，分析以下构成比（R）大小：（a）按酗酒年限分组，各组中As相关病人数在165人中的R（a）；（b）按日均酒精量分组，各组中As相关病人数在165人中的R（b）；（e）按疾病种类分组，各组中酗酒病人数在该组病人数中的R（c）。（2）随机选择酗酒脂肪肝（F）44人，酗酒非脂肪肝（N）32人，健康对照（C）50人，测定以下指标：（a）血脂：甘油三酯（TG），总胆固醇（TC），低密度脂蛋白胆固醇（LDL-C），高密度脂蛋白胆固醇（HDL-C）。（b）肝功能：丙氨酸转氨酶（ALT），γ-谷氨酰转移酶（GLT），胆碱脂酶（CHE），总胆汁酸（TBA），总胆红素（TBil）。禁酒1月后复查。结果（1）R（a）随酗酒年限而增大，R（b）随日均酒精量而增大，R（c）在87．50％～94．11％之间。（2）F，N组中，LDL-C，HDL-C无变化，而TG，TC增高；两组Tbil和N组CHE无变化，而两组ALT，GLT，TBA和F组CHE增高；禁酒1月后，两组TG，TC．LDL．C，HDL-C，Tbil，CHE无变化，而ALT，GLT仍高于C组。结论酗酒是汉人As的危险因子，其机制与慢性肝细胞损伤致脂质代谢紊乱有关。

英文摘要：

Objective The relationship and its mechanisms between heavy alcohol intake and atherosclerosis （As） were studied via epidemiological investigations. Methods （ 1 ） 165 male patients with As - related diseases （see below） were selected randomly, including 43 angina patients, 31 myocardial infarction patients, 8 myocardial fibrosis patients, 51 cerebral infarction patients and 32 cerebral haemorrhage patients. Three kinds of constituent ratios were studied： （a）According to alcohol consumption years, all 165 patients were divided into 4 groups （hardly consumed, 〈 5 years, 5 - 10 years, 〉 10 years） . In every group of patients, ratios of As - related patients count to 165 （patients） were studied. （b）According to alcohol consumption quantity, all 165 patients were divided into 3 groups （ hardly consumed, ≤300 ml/day, 〉 300 ml/day）. In every group of patients, ratios of As - related patients count to 165 （patients） were studied. （c）According to single disease, all 165 patients were divided into 5 groups （ angina, myocardial infarction, myocardial fibrosis, cerebral infarction, cerebral haemorrhage）. （2） 44 heavy alcohol intake ＆ fatty liver men, 32 heavy alcohol intake ＆ non - fatty liver men, 50 healthy men were selected randomly, and some of their serum data were measured, including： （a） blood lipid： triglyeeride （ TG）, total cholesterol （TC）, low density lipoprotein cholesterol （LDL-C） and high density lipoprotein cholesterol （HDL-C） ; （b）liver function ： alanine aminotransferase （ ALT）, 5,-glutamyhransferase （ GLT）, cholinesterase （ CHE ） , total bile acid （TBA） and total bilirubin （TBil）. After 1 month of alcohol temperance the above data were measured again. Results （ 1 ） Constituent ratios 1 increased with the alcohol consumption years, constituent ratios 2 increased with the alcohol consumption quantity, and constituent ratios 3 were 87.50% - 94, 11%. （ 2 ） In both groups of heavy alcohol inta