中文摘要：

地方性砷中毒是我国政府高度重视的地方病，但受砷致病机制不明、缺乏癌变早期诊断指标以及无特效治疗药物等限制，地方性砷中毒尚未得到彻底控制。近年来国内外学者从分子、细胞、组织与系统等多个水平与层次对砷毒作用机制进行了较深入的研究，取得了一系列成果，也形成了一些假说。但同时也存在机制研究各自为政，各假说间缺乏相互联系，机制研究与转化应用衔接不够致应用价值有限等问题。因此，加强地方性砷中毒机制假说间相互作用及其转化应用研究，对推进科学防控地方性砷中毒有重要意义。

英文摘要：

Endemic arsenicosis is one of the national key endemic diseases in our country. However, due to obscure mechanism of arsenic poisoning, lack of early diagnostic indicators and specific validated therapy, the ideal control of endemic arsenicosis has not yet been obtained. To date, considerable progress has been made to address endemic arsenic poising and also formed various hypotheses, whereas simultaneously there are some problems and the insufficiency such as unclear relationship among those hypotheses and the gap between mechanism studies and translational application. In consequence, enhancing the interactive effects among various mechanisms of arsenic poising and improving its translational application could have more realistic significance for scientific prevention and control of endemic arsenicosis.