胸腺是一个主要淋巴的机关,能产生最后开拓殖民地于第二等的淋巴的机关的成熟 T 房间,并且为外部 T 因此是必要的房间更新。最近的数据证明正常 thymocyte 出口能被几个影响因素包括几 chemokines 改变, sphingosinel 磷酸盐(S1P ) ,抄写因素象 Foxjl 那样,象 Kruppel 一样抄写因素 2 (KLF2 ) 并且抗原刺激,等等。在这评论,我们在 thymic 输出关于学习策略,影响因素和可能的分子的机制总结了最近的报告。
Thymus is a primary lymphoid organ, able to generate mature T cells that eventually colonize secondary lymphoid organs, and is therefore essential for peripheral T cell renewal. Recent data showed that normal thymocyte export can be altered by several influence factors including several chemokines, sphingosinel-phosphate (S1P), transcription factors such as Foxjl, Kruppel-like transcription factor 2 (KLF2) and antigen stimulation, etc. In this review, we summarized the recent reports about study strategies, influence factors and possible molecular mechanisms in thymic output. Cellular & Molecular Immunology.