中文摘要：

目的 研究特发性全面性癫痫（idiopathic generalized epilepsy,IGE）患者元记忆监测情况,探讨IGE患者记忆障碍的可能机制.方法 建立情景记忆（episodic memory,EM）与语义记忆（se-mantic memory,SM）知晓感（feeling of knowing,FOK）的实验范式,对31例IGE患者与30例在年龄、性别及教育程度相匹配的健康对照者进行研究.结果 与健康对照组（HC组）的情景记忆知晓感（FOK-EM）的FOK判断准确率[（85.29±16.84）％]及语义记忆知晓感（FOK-SM）的线索回忆成绩[（76.61±18.66）％]比较,癫痫患者组（IGE组）FOK-EM的FOK判断准确率[（64.03±22.10）％]及FOK-SM的线索回忆成绩[（53.27±26.91）％]显著降低,差异有统计学意义（t=-4.215,P＜0.01;t=-3.677,P＜0.01）;IGE组FOK-EM的肯定判断/正确再认成绩[（51.16±32.93）％]及否定判断/正确再认成绩（即低估）[（21.07±24.38）％]与HC组的肯定判断/正确再认成绩[（79.34±27.26）％]及否定判断/正确再认成绩[（2.45±5.38）％]之间差异有统计学意义（t=-3.634,P＜0.01;t=4.149,P＜0.01）;FOK-EM的否定判断/正确再认（低估）成绩与正序、逆序数字广度测试、词汇流畅性测试及Stroop效应相关（r=-0.309,P＜0.05;r=-0.355,P＜0.01;r=-0.354,P＜0.05;r=0.602,P＜0.01）.结论 IGE患者情景记忆监测受损,表现为对自己再认能力的低估;这种记忆监测受损与执行功能障碍相关,提示IGE患者的执行功能障碍可能是导致其情景记忆监测能力受损的主要机制;同时患者的语义记忆监测相对保留,提示情景记忆监测与语义记忆监测可能依赖不同的神经机制.

英文摘要：

Objective To investigate the memory monitoring ability in patients with idiopathic generalized epilepsy （IGE） and explore the mechanism of the memory impairment.Methods The feeling of knowing （FOK） paradigm of episodic memory （EM） and semantic memory （SM） were established and subsequently administered in 31 patients with IGE （IGE group） and 30 healthy controls （HC group） participants who were matched in age,sex and educational level.Results Compared with HC group （feeling of knowing of episodic memory （FOK-EM） FOK accuracy （85.29± 16.84） ％;feeling of knowing of sematic memory （FOK-SM） recall （76.61± 18.66） ％）,the FOK-EM FOK accuracy （（64.03± 22.10） ％） and FOK-SM recall （（53.27±26.91） ％） in IGE group were significantly decreased（t=-4.215,P＜0.01;t=-3.677,P＜0.01）.The correct judgment and correct recognition of FOK-EM （（51.16±32.93） ％） and the false judgment and correct recognition （（21.07±24.38） ％） of FOK-EM in the IGE group were significantly different with the HC group （the correct judgment and correct recognition of FOK-EM：（79.34±27.26）％ and the false judgment and correct recognition of FOK-EM：（2.45±5.38） ％;t=-3.634,P＜0.01;t=4.149,P＜0.01）.Most importantly,the false judgment and correct recognition of FOK-EM were correlated with the Digital Span Test,Vocabulary Fluency Test and the Stroop effect in IGE group （r=-0.309,P＜0.05;r=-0.355,P＜0.01;r=-0.354,P＜0.05;r=0.602,P＜0.01）.Conclusion The results show that the IGE group made less accurate metamemory monitoring than the HC group by underestimating their memoU performance on FOK-EM,whereas the semantic metamemory monitoring is not impaired in IGE group.More importantly,the impairment of memory monitoring was correlated with the deficit of executive function,indicating that this mechanism can be an influential factor of memory disorder in IGE.It also indicates that the episodic and semantic metamemory monitoring depend on different