中文摘要：

为确认环渤海水域中抗生素的污染情况,对渤海各主要河流入海处的磺胺类抗生素含量状况进行调查.采用高效液相色谱-串联质谱法对14种磺胺类药物进行分析,外标法定量.经检测得出磺胺类化合物的质量浓度∶磺胺醋酰（SAAM）为2.1～4.4 ng/L,磺胺嘧啶（SDZ）为5.7～12.9 ng/L,磺胺甲基异唑（SMZ）为3.6～13.0 ng/L,磺胺噻唑（STZ）为9.2～32.2 ng/L,磺胺甲噻唑（SMTZ）为5.3～6.2 ng/L,磺胺氯哒嗪（SCP）为2.2 ng/L,磺胺间二甲氧嘧啶（SDM）为2.7～2.9 ng/L.检测结果表明,城市生活污水排放是环渤海水域磺胺类污染物的主要来源,对环境微生态系统已造成严重影响.

英文摘要：

Samples from the surface water of the main rivers which flow into Bohai sea were investigated to determine the pollution level of antibiotics in water column around Bohai sea. The occurrence of fourteen sulfonamides drugs were studied using high performance liquid chromatography-electrospray ionization tandem mass spectrometry with multiple reaction monitoring （MRM）. The concentrations of sulfonamide compounds were as follows, SAAM 2.1 - 4.4 ng/L, SDZ 5.7 - 12.9 ng/L, SMZ 3.6 - 13.0 ng/L, STZ 9.2 - 32.2 ng/L, SMTZ 5.3 - 6.2 ng/L, SDM 2.7 - 2.9 ng/L and SCP 2.2 ng/L. The result shows that municipal wastewater discharge is the most important source of sulfonamides in Bohai sea water column which may have serious effect on environmental microcosm.