中文摘要：

目的观察益力多对COPD患者肠内营养相关性腹泻的预防作用。方法将160例COPD患者随机分为观察组与对照组各80例。观察组在胃肠内注入肠内营养剂加益力多，对照组常规加入肠内营养剂，观察两组患者7d内腹泻的发生率及菌群失调情况。结果观察组10例患者发生腹泻，发生率为12．50％；对照组33例患者发生腹泻，发生率为41．25％；在革兰球菌比重≥40％的患者中，观察组有10例，占12．50％，对照组有36例,占45．00％；观察组患者达到营养目标供给量的时间和营养支持治疗的时间短于对照组,两组间比较,差异均有统计学意义（P〈0．05）。结论益力多干预可减少COPD患者菌群失调性腹泻的发生，提高肠内营养的成功率。

英文摘要：

Objective To observe the preventive effect of Yakuh for enteral nutrition related diarrhea of patients with COPD. Methods One hundred and sixty patients with COPD were randomly assigned into observation group and con- trol group, 80 cases in each group. The observation group was treated by gastrointestinal injection of enteral nutrition agent plus Yakult, while the control group was treated by conventional enteral nutrition agent. The incidence of diar- rhea within 7 d and the flora imbalance of patients in both groups were observed and classified. Results There were 10 cases of diarrhea in observation group with incidence of 12.50%, while 33 cases in control group with incidence of 41.25%. There were 10 patients （12.50%） with Gram-cocci proportion ≥ 40% in observation group, while 36 patients （45.00%） in control group. The time of achieving the supply amount of nutritional target and treatment time of nutrition- al support of patients in observation group were shorter than those of corresponding items in control group, and the difference were all statistically significant （P 〈 0.05）. Conclusion The intervention of Yakuh can reduce the occurrence of diarrhea caused by flora imbalance and improve the success rate of enteral nutrition.