阿尔采末病是一种神经退行性疾病,在老年人疾病谱中的地位日益突出,其发病机制未完全明了,无理想的治疗药物。新近研究证实,硫化氢具有抗氧化、抗凋亡、抗炎作用,在阿尔采末病的发生、发展过程中扮演重要角色。本文综述了硫化氢的生物学特点及作用,特别强调了硫化氢在阿尔采末病病理生理学中的保护作用,旨在为后续研究该病的治疗药物提供新思路。
Alzheimer disease (AD) is a neurodegenerative disease and stands increasingly prominent position in the disease spectrum of the elderly. Its pathogenesis drugs are unavailable yet. Recent studies clearly indicate that hy apoptotic, and anti-inflammatory effects and plays an important This review summarizes biological characters and actions of H2S, is still fully unknown and the ideal treatment drogen sulfide (H2S) exerts antioxidant, anti- role in the occurrence and development of AD. especially highlights the actions of H2S on AD pathophysiology, in order to provide a new strategy for subsequent AD therapy.