中文摘要：

世界范围内细菌耐药性问题日益严重状况下,包括铜绿假单胞菌（Pseudomonas aeruginosa,PA）在内的病原微生物的致病性与耐药性的共选择、共进化现象引起了人们越来越多的关注和不断深入的研究,这将有助于优化临床治疗方案,为药物治疗和筛选提供新靶点.本文综述了PA致病性与耐药性共选择机制的遗传物质基础,并简单讨论二者变化关系及相关应用.

英文摘要：

Antibiotics resistance of bacteria has accelerated around the world nowadays. More and more multidrug-resistant pathogens with increased pathogenicity emerged in clinic and caused much more problems in human health all over the world. Co-selection is one of the most important mechanisms that favor the persistence of the resistant pathogens and the selection of the most virulent and most resistant pathogens. Pseudomonas aeruginosa is an important pathogen, capable of causing serious and often life-threatening infection in humans because of its resistance to many kinds of antibiotics as well as the large arsenal of virulence factors. P aeruginosa has joined the ranks of these most virulent and most resistant ＂superbug＂. The progress on the co-selection of resistance and virulence in P. aeruginosa and the sequent aoolication in clinic have been reviewed in this oaoer.