中文摘要：

测量血 T 房间子集， Th1 ， Th2 ， Th17 ， Th22 ，和 Treg 房间的比例的目的，和在有在有 Yiqi Tongyang 煎的治疗前后的长期的有免疫力的 thrombocytopenia ( CITP )的病人的另外的参数(， YTD )与 CITP 探索病人的 T 房间地位，并且到 defifine YTD 的行动的机制。方法在有 CITP ( 22 女性和 8 男性)的 30 个病人的 Th1 ， Th2 ， Th17 ， Th22 ，和 Treg 房间的在外部血 T 淋巴细胞子集的变化，和那些与 YTD 在治疗前后用 multiparametric flflow cytometry 被分析 6 个月，并且 26 个健康志愿者( 14 男性和 12 女性)充当了控制。在 T 房间(T 赌注) 和 GATA 有约束力的蛋白质表示的 T 盒子 3 (GATA-3 ) 在病人和控制的 mRNA 层次用即时反向的抄写聚合酶链反应被分析。Th1， Th17， Th22， Th1/Th2，和 Th17/Treg 房间的比例在 YTD 治疗前在控制与那些相比与 CITP 在病人的外部血增加了的结果(P < 0.05 ) 。Th1 房间数字和 Th1/Th2 比率与 CITP 掉在对待的病人里接近控制组的价值(P > 0.05 ) 。Th17 房间数字和 Th17/Treg 比率也在治疗组减少了(P < 0.05 ) ，然而并非到控制的层次。在有在治疗前的 CITP 的病人的外部血的 Treg 房间的数字在控制组是比那低的(P < 0.05 ) ，但是在 YTD 治疗 P 以后增加了 < 0.05 ) ，然而并非到控制的水平。在外部血的 T 赌注和 GATA-3 mRNA 层次比控制在在治疗前的病人是开始更高的(P < 0.05 ) ，但是在 YTD 治疗以后减少了(P < 0.05 ) 。在 T 淋巴细胞层次的结论不平衡，特别地那些 Th1/Th2 和 Th17/Treg 房间，在 CITP 的致病起重要作用。YTD effificiently 调整了 Th1/Th2 和 Th17/Treg equilibria 的动力学。

英文摘要：

Objective： To measure the proportions of blood T cel subsets, Th1, Th2, Th17, Th22, and Treg cel s, and other parameters in patients with chronic immune thrombocytopenia（CITP） before and after treatment with Yiqi Tongyang Decoction（益气通阳方, YTD） to explore T cel status of patients with CITP, and to define the mechanism of action of YTD. Methods： The changes in peripheral blood T lymphocyte subsets, and those of Th1, Th2, Th17, Th22, and Treg cel s in 30 patients with CITP（22 females and 8 males） were analyzed using multiparametric flow cytometry before and after treatment with YTD for 6 months, and 26 healthy volunteers（14 males and 12 females） acted as a control. T-box expressed in T-cel s（T-bet） and GATA binding protein 3（GATA-3） m RNA levels in patients and controls were analyzed using real-time reverse transcription-polymerase chain reaction. Results： The proportions of Th1, Th17, Th22, Th1/Th2, and Th17/Treg cells increased in the peripheral blood of patients with CITP compared to those in controls before YTD therapy（P〈0.05）. Th1 cel numbers and the Th1/Th2 ratio fel in the treated patients with CITP to approximate the values of the control group（P〉0.05）. Th17 cel numbers and the Th17/Treg ratio also decreased in the treatment group（P〈0.05）, but not to the levels of the controls. The number of Treg cel s in the peripheral blood of patients with CITP before treatment was lower than that in the control group（P〈0.05）, but increased after YTD treatment（P〈0.05）, but not to the level of controls. T-bet and GATA-3 m RNA levels in peripheral blood were initially higher in patients before treatment than controls（P〈0.05）, but decreased after YTD therapy（P〈0.05）. Conclusions： Imbalances in T lymphocyte levels, particularly those of Th1/Th2 and Th17/Treg cel s, play important roles in the pathogenesis of CITP. YTD efficiently regulated the dynamics of Th1/Th2 and Th17/Treg equilibria.