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微量热法研究头孢菌素对大肠杆菌微生物活性的影响
  • ISSN号：0251-0790
  • 期刊名称：《高等学校化学学报》
  • 时间：0
  • 分类：O642.3[理学—物理化学;理学—化学]
  • 作者机构：[1]中国科学院大连化学物理研究所材料热化学实验室,大连116023, [2]中国科学院研究生院,北京100049, [3]中国科学院大连化学物理研究所生物质高效转化课题组,大连116023, [4]湖南省药品检验所,长沙410001
  • 相关基金：基金项目：国家自然科学基金（批准号：50671098,20473091,20573112）资助.
作者： 杨黎妮[1,2], 孙立贤[1], 徐芬[1], 赵宗保[3], 梁建国[4]
关键词： 微量热法, 抑制作用, 头孢菌素, 大肠杆菌, Microcalorimetry , Inhibition fuction , Cephalosporin, E. coli DH5α
中文摘要：

用微量热法测定了两种头孢菌素头孢哌酮钠（CFZ）和头孢哌酮钠舒巴坦钠（CFZ-SBT）在37℃时对大肠杆菌DH5α代谢作用的影响。根据产热曲线分别获得了大肠杆菌DH5α在不同浓度的头孢哌酮钠和头孢哌酮钠舒巴坦钠作用下的生长速率常数（k）、抑制率（I）、最大产热功率（Pm）以及最大产热功率所对应的时间tm等热动力学参数。研究结果表明，头孢哌酮钠和头孢哌酮钠舒巴坦钠对大肠杆菌的致死量分别为0．1和0．25μg／mL。通过研究k，I，Pm，tm和浓度（c）间的关系发现，舒巴坦钠的加入没有增加头孢哌酮钠对大肠杆菌DH5α的抑制作用。

英文摘要：

The effects of Cefoperazone Sodium（CFZ） and Cefoperazone Sodium ＆ Sulbactam Sodium for in- jection（CFZ-SBT） on the metabolism of Escherichia coli （.E. coli） DH5α were studied by microcalorimetry. The microbial activity was recorded as power-time curves through an ampoule method with a TAM air isothermal microcalorimeter at 37℃. The parameters such as the growth rate constant（k）, inhibitory ratio（I）, the maximum power output（Pm） and the time（tm） corresponding to the maximum power output were obtained. The lethal doses of CFZ and CFZ-SBT were calculated as 0. 1 and 0. 25 μg/mL, respectively. Moreover, according to the relationship between k, Pm, tm and c, the conclusion could be made that the CFZ-SBT cannot improve the inhibitory effect on E. coli DH5α in comparison with the CFZ.

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期刊信息
  • 《高等学校化学学报》
  • 北大核心期刊（2011版）
  • 主管单位:中华人民共和国教育部
  • 主办单位:吉林大学 南开大学
  • 主编：周其凤
  • 地址：吉林大学南胡校区
  • 邮编：130012
  • 邮箱：cjcu@jlu.edu.cn
  • 电话：0431-88499216
  • 国际标准刊号：ISSN：0251-0790
  • 国内统一刊号：ISSN：22-1131/O6
  • 邮发代号:12-40
  • 获奖情况:
  • 首届及第二届国家期刊奖,连续两届“百种中国杰出学术期刊”,中国期刊方阵“双高”期刊
  • 国内外数据库收录:
  • 俄罗斯文摘杂志,美国化学文摘（网络版）,荷兰文摘与引文数据库,美国工程索引,美国科学引文索引（扩展库）,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊（2004版）,中国北大核心期刊（2008版）,中国北大核心期刊（2011版）,中国北大核心期刊（2014版）,英国英国皇家化学学会文摘,中国北大核心期刊（2000版）
  • 被引量:50676