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黄连粉末中盐酸小檗碱及盐酸药根碱的体内肠吸收特性
  • ISSN号:1672-0741
  • 期刊名称:华中科技大学学报(医学版)
  • 时间:2013.6.15
  • 页码:333-337
  • 分类:Q255[生物学—细胞生物学] TS201.25[轻工技术与工程—食品科学;轻工技术与工程—食品科学与工程]
  • 作者机构:[1]Institute of Integrated Traditional Chinese and WesternMedicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan (430030), China, [2]Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan (430030), China
  • 相关基金:Supported by the National Natural Science Foundation of China (No. 81173370)
  • 相关项目:基于黄连粉末中Hdber的追踪研究探讨黄连粉末治疗消渴症的科学内涵
中文摘要:

在老鼠为 hyperlipidemia 的处理调查效果和 8-hydroxy dihydroberberine (Hdber ) 的不同剂量的分子的机制。

英文摘要:

Objective: To investigate the effect and molecular mechanisms of different doses of 8-hydroxy dihydroberberine (Hdber) for the treatment of hyperlipidemia in rats. Methods: A rat model of hyperlipidemia was established by feeding rats a high-fat diet for 4 weeks in 70 rats of 80 animals, and 10 rats were randomly selected as control group. The hyperlipidemic rats were then randomly divided into the following groups: a model group (MOD); a berberine group [BBR, 156 mg/(kg.day)]; Hdber groups, which were treated with different doses of Hdber [78, 39 and 19.5 mg/(kg.day)]; and a simvastatin group [SIM, 4 mg/(kg.day)]. The corresponding therapy was administered to the rats of each treatment via gastric tubes. Normal animals were used as a control group. The blood levels of various lipids, including total cholesterol, triglycarides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, free fatty acid (FFA), apolipoprotein A I (Apo-A I ) and apolipoprotein B (APO-B) were examined. The protein expressions of low-density lipoprotein receptor (LDL-R), sterol regulatory element-binding protein 2 (SREBP-2), 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) and proprotein convertase subtilisin/kexin type 9 (PCSK-9) in liver tissues were determined by Western blot analysis. Results: Compared with the control group of rats, the model group demonstrated a deteriorated blood lipid profile and exhibited increased expression levels of PCSK-9 protein in their liver tissues (P〈0.01). In addition, the high-fat diet decreased the expression levels of LDL-R, SREBP-2 and HMGCR proteins in murine liver tissues. However, the addition of berberine or Hdber reversed the blood lipid profile changes (P〈0.05 or P〈0.01), decreased the expression levels of PCSK-9 proteins (P〈0.01), and increased the expression levels of LDL-R proteins in the hyperlipidemic rats (P〈0.01). These compounds did not significantly influence the expression leve

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期刊信息
  • 《华中科技大学学报:医学版》
  • 北大核心期刊(2011版)
  • 主管单位:教育部
  • 主办单位:华中科技大学
  • 主编:陈建国
  • 地址:武汉航空路13号
  • 邮编:430030
  • 邮箱:zhengm@mail.tjmu.edu.cn
  • 电话:027-83692530
  • 国际标准刊号:ISSN:1672-0741
  • 国内统一刊号:ISSN:42-1678/R
  • 邮发代号:38-37
  • 获奖情况:
  • 1996年第二届全国优秀科技期刊二等奖,1999年全国高等学校优秀自然科学学报一等奖,1999年湖北省出版佳作奖、省优秀期刊,2006年湖北省优秀科技期刊,2) 2008年教育部第二届中国高校优秀科技期刊奖,2010年教育部第三届中国高校优秀科技期刊奖,2011年第七届湖北省医学优秀精品期刊
  • 国内外数据库收录:
  • 美国化学文摘(网络版),英国农业与生物科学研究中心文摘,波兰哥白尼索引,中国中国科技核心期刊,中国北大核心期刊(2008版),中国北大核心期刊(2011版),中国北大核心期刊(2014版)
  • 被引量:10596