中文摘要：

目的研究慢性间歇性低氧对大鼠血压和交感神经活动的影响。方法将雄性SD大鼠随机分为正常对照组和慢性间歇性低氧模型组（CIH），每组20只，分别采用无创套尾法监测大鼠尾动脉收缩压（SBP）随间歇性低氧时间的变化，在体记录大鼠的平均动脉压（MAP）和肾交感神经活动（RSNA），以及采用ELISA检测大鼠血浆中去甲肾上腺素（NE）的水平。结果间歇性低氧15d后，CIH组SBP、MAP和RSNA较对照组明显升高；CIH组大鼠血浆中NE的含量较对照组明显升高（均P〈0．05）。结论慢性间歇性低氧可引起大鼠血压升高和交感神经活动过度增强。

英文摘要：

Objective To investigate the effects of chronic intermittent hypoxia （CIH） on blood pressure and sympathetic nerve activity in rats. Methods Male SD rats （n =40） were randomly divided into control and CIH groups. The conscious noninvasive method with tail cuff was performed in rats to record the systolic blood pressure （SBP） after exposure to 5 , 10,15 days of CIH. Mean arterial pressure （MAP）, heart rate （HR） and renal sympathetic nerve activity （RSNA） were recorded in vivo on PowerLab data-acquisition systems, while plasma norepinephrine （NE） was measured after CIH. Results SBP, MAP and RSNA were significantly enhanced in CIH group compared to those of control group after 15 days of CIH, and the plasma NE level of ratic CIH group was significantly higher than that of the control group. Conclusions CIH can induce increased blood pressure and sympathetic overactivity in rats.